Please read this note I posted last January about hypoperfusion (slow blood flow) and the MS brain. Many researchers had noted this phenomena before Dr. Zamboni came forward with his discovery of CCSVI. Slow blood can create an hypoxic (low oxygen) situation in the brain, and this in itself can damage brain tissue, causing axonal death and activating the immune system. Here is the note:
http://www.facebook.com/note.php?note_id=229656952210
Remember, the autoimmune theory of MS is still just a theory. Doctors have never proven that MS is started by the immune system.
Here is a wonderful editorial on this topic by Dr. Peter Behan, called
"The Futility of the autoimmune orthodoxy in multiple sclerosis research"
"...a false orthodoxy claiming that multiple sclerosis is an autoimmune disorder has developed and formed the present basis of treatment, drug trials and research. The outcome of this misplaced creed has been truly catastrophic.”
http://www.expert-reviews.com/doi/pdf/10.1586/ern.10.69
If you are curious as to how CCSVI could cause lesions and brain and spinal damage in MS, please, read this note and the paper I have linked. Yes, it is very technical, but I break it down into chunks, and explain what the researchers found.
Again, Here's the Note
http://www.facebook.com/note.php?note_id=229656952210
No matter what neurologists may claim, they have never proven that MS is a purely autoimmune driven disease. Researchers have noted that in the beginning the lesions look like ischemic (low oxygen) events, even before the immune system is activated. Here is a link to Lassmann's paper on this: http://www.ncbi.nlm.nih.gov/pubmed/12559509
Here is a paper by Prineas and Barnett--where they study fresh lesions upon autopsy, and discover that there is axonal death without ANY immune activation: This discovery makes them question EAE as a model for MS.
Relapsing and Remitting Multiple Sclerosis: Pathology of the Newly Forming Lesion
Michael H. Barnett, MBBS and John W. Prineas, MBBS
The study describes the clinical and pathological findings in 12 patients with relapsing and remitting multiple sclerosis,
who died during or shortly after the onset of a relapse. Pathological changes not previously associated with the formation of new symptomatic lesions were observed in seven cases, namely, extensive oligodendrocyte apoptosis and microglial activation in myelinated tissue containing few or no lymphocytes or myelin phagocytes. No current laboratory model of multiple sclerosis, in particular, experimental allergic encephalomyelitis, is known with these features, which raises the possibility of some novel process underlying new lesion formation in multiple sclerosis.
http://www.cpnhelp.org/files/Ref1_Annals04.pdf
It is vitally important that we understand the science behind Dr. Zamboni's discovery, in order to be informed patients and caregivers. Slowed venous drainage can create slowed perfusion....just like all those researchers noted in MS brains. There will continue to be much push back from the status quo. They need to maintain the current dogma on MS, in order to keep their jobs and pharmaceutical ties. But we need to ask, How do you KNOW MS is initiated by the immune system? Have you read the other research??
Be informed. Read the research. It's not snake oil. It's scientific fact.
http://www.facebook.com/note.php?note_id=229656952210
Remember, the autoimmune theory of MS is still just a theory. Doctors have never proven that MS is started by the immune system.
Here is a wonderful editorial on this topic by Dr. Peter Behan, called
"The Futility of the autoimmune orthodoxy in multiple sclerosis research"
"...a false orthodoxy claiming that multiple sclerosis is an autoimmune disorder has developed and formed the present basis of treatment, drug trials and research. The outcome of this misplaced creed has been truly catastrophic.”
http://www.expert-reviews.com/doi/pdf/10.1586/ern.10.69
If you are curious as to how CCSVI could cause lesions and brain and spinal damage in MS, please, read this note and the paper I have linked. Yes, it is very technical, but I break it down into chunks, and explain what the researchers found.
Again, Here's the Note
http://www.facebook.com/note.php?note_id=229656952210
No matter what neurologists may claim, they have never proven that MS is a purely autoimmune driven disease. Researchers have noted that in the beginning the lesions look like ischemic (low oxygen) events, even before the immune system is activated. Here is a link to Lassmann's paper on this: http://www.ncbi.nlm.nih.gov/pubmed/12559509
Here is a paper by Prineas and Barnett--where they study fresh lesions upon autopsy, and discover that there is axonal death without ANY immune activation: This discovery makes them question EAE as a model for MS.
Relapsing and Remitting Multiple Sclerosis: Pathology of the Newly Forming Lesion
Michael H. Barnett, MBBS and John W. Prineas, MBBS
The study describes the clinical and pathological findings in 12 patients with relapsing and remitting multiple sclerosis,
who died during or shortly after the onset of a relapse. Pathological changes not previously associated with the formation of new symptomatic lesions were observed in seven cases, namely, extensive oligodendrocyte apoptosis and microglial activation in myelinated tissue containing few or no lymphocytes or myelin phagocytes. No current laboratory model of multiple sclerosis, in particular, experimental allergic encephalomyelitis, is known with these features, which raises the possibility of some novel process underlying new lesion formation in multiple sclerosis.
http://www.cpnhelp.org/files/Ref1_Annals04.pdf
It is vitally important that we understand the science behind Dr. Zamboni's discovery, in order to be informed patients and caregivers. Slowed venous drainage can create slowed perfusion....just like all those researchers noted in MS brains. There will continue to be much push back from the status quo. They need to maintain the current dogma on MS, in order to keep their jobs and pharmaceutical ties. But we need to ask, How do you KNOW MS is initiated by the immune system? Have you read the other research??
Be informed. Read the research. It's not snake oil. It's scientific fact.
The Combination Therapy includes neck vein dilatation based on the findings of Zamboni, et al. The vein dilatation or venoplasty therapy provides the appropriate drainage of the CNS that prevents a retrograde pressure exertion on the myelin sheath covering the CNS. Whatever triggers the autoimmune system to turn on in people predisposed to MS, this back-pressure needs to be resolved. In case after case, the typical symptoms of MS retreat in individuals where the veins are expanded and the flow pressures are equalized. Since keeping the jugular and azygous veins fully open is the key to reducing MS symptoms, it is of paramount importance to know what other post-procedure factors create enduring effect in the venous flow. For example, there is now good clinical and observational evidence to support the fact that stem cells (transplanted intravenously at the time of the venoplasty) reduce swelling, thrombin buildup, clotting and subsequent permanent intraluminal damage leading to scar tissue. As to what has already been established through clinical trials and subsequent therapeutic practice, it has been found that even in patients with severely malformed or abnormal jugular vein structure, the intravenous introduction of autologous stromal cells (MSCs) post-operatively has served to repair injury attributable to venoplastic damage and desquamation of the endothelial and subendothelial cells of the interior venous lumen (tunica intima). Peak velocity, time average velocity vein area, and flow quantification have been assessed by means of echo color Doppler at periodic intervals post-venoplasty. Significant hemodynamic improvement has been recorded at the level of the veins in the neck post-venoplasty. Moreover, this additional stem cell transplantation therapy has led to increased luminal diameter and improved patency rates demonstrating that the introduction of stem cells post-operatively significantly modifies the hemodynamics of the jugular veins more effectively than venoplasty alone.For more information please visit http://www.ccsviclinic.ca/?p=1194 or you may call the toll free number at 888-468-1554 or info@ccsviclinic.com
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