- The MS lesion: caused by hypoperfusion?
- A potential physiological link between MS and depression
- Effects of hypoxia on the brain
- Increased neuronal vulnerability following hypoxia/ischaemia
- The Big Idea: Iron-dependent inflammation in venous disease and proposed parallels with MS
- 1. Rindfleisch E. - "Histologisches detail zu der grauen degeneration von gehirn und ruckenmark". Archives of Pathological Anatomy and Physiology. 1863;26:474–483
2. Putnam, T.J. (1937) Evidence= of vascular occlusion in multiple sclerosis
3. VASCULAR PATTERN OF LESIONS OF MULTIPLE SCLEROSIS Arch Neurol Psychiatry. 1942;47(1):1-18
4. Zimmerman, H. M., Netsky, M. G.: The pathology of multiple sclerosis. Res. Publ. Ass. Nerv. Ment. Dis. New York 28, 271--312 (1950)
5. Fog Torben, The topography of plaques in multiple sclerosis, with special reference to cerebral plaques. Acta Neurol Scand, 41,Suppl. 15:1, 1965) Fog T. On the vessel-plaque relations in the brain in multiple sclerosis.ActaPsychiat Neurol Scand. 1963; 39, suppl. 4:258
- Tracey Putnam, Boston City Hospital,
developed an experimental dog model of
venous obstruction to study MS. His work
supports the recent rediscovery of this concept
by Dr. Paolo Zamboni of Italy.
“The similarity between such lesions
and many of those seen in cases of
multiple sclerosis in man is so striking
that the conclusion appears almost
inevitable that venular obstruction is
the essential immediate antecedent to
the formation of typical sclerotic
Putnam (1935). Studies in multiple sclerosis: encephalitis and sclerotic plaques
produced by venular obstruction. Archives of Neurology and Psychiatry. 33: 929-940.'
- Dr Haake and Dr Hubbard discussing imaging in CCSVI
- Internal jugular vein valve problems and other brain function problems
- Intracranial venous haemodynamics in MS
- Multiple Sclerosis - a vascular aetiology ?
- Prof Zamboni's preliminary results , the liberation procedure
- CCSVI proposed
- A brief history of the early venous vascular observations in MS - Dr M Haake
- German doctors link neurological problems and Internal Jugular Vein problems in 2005
Research on MS and cerebrovascular problems
While trawling around for CCSVI information, I came across a number of research papers making the link between poor venous circulation in the brain, iron deposits and MS. There are plenty more out there if you are willing to look, after all this idea has only been around 150 years......